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Palladium‐Catalyzed Intermolecular Ene–Yne Coupling: Development of an Atom‐Efficient Mizoroki–Heck‐Type Reaction
Author(s) -
Lindhardt neé Hansen Anders T.,
Mantel Mette Louise H.,
Skrydstrup Troels
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705558
Subject(s) - chemistry , palladium , catalysis , intermolecular force , heck reaction , alkyl , atom economy , medicinal chemistry , atom (system on chip) , amide , combinatorial chemistry , polymer chemistry , organic chemistry , molecule , computer science , parallel computing
Direct and to the point : A palladium(II) catalytic system based on a palladium hydride species provides access to highly substituted 1,3‐dienes through a direct coupling of alkynes with alkenes in a base‐free Mizoroki–Heck‐type reaction with full atom economy (see scheme; R=amide, borate, C(OH)Me 2 , Oalkyl).