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Total Synthesis and Structure Assignment of Papuamide B, A Potent Marine Cyclodepsipeptide with Anti‐HIV Properties
Author(s) -
Xie Weiqing,
Ding Derong,
Zi Weiwei,
Li Guangyu,
Ma Dawei
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705557
Subject(s) - total synthesis , human immunodeficiency virus (hiv) , stereochemistry , chemistry , depsipeptide , computational biology , biology , virology
Synthesis in stereo : The first total synthesis of papuamide B, a cyclic peptide isolated from a marine sponge, has been achieved. The configuration of three stereogenic centers of its dienoic acid unit has been established by comparison to a series of stereoisomers of known configuration, and the stereochemistry of its 2,3‐diaminobutanoic acid segment has been revised.