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Kinetics of Iminium Ion Catalysis
Author(s) -
Evans Gareth,
Gibbs Timothy J. K.,
Jenkins Robert L.,
Coles Simon J.,
Hursthouse Michael B.,
Platts James A.,
Tomkinson Nicholas C. O.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705539
Subject(s) - iminium , bottleneck , cycloaddition , catalysis , catalytic cycle , computer science , chemistry , combinatorial chemistry , organic chemistry , embedded system
Identifying the bottleneck : Kinetic and computational data for the key steps of the iminium ion catalyzed Diels–Alder reaction show that the cycloaddition (step II in scheme) is the rate‐determining step of the catalytic cycle and provide a rationale for developing more‐active catalyst architectures.