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Copper‐Free Azide–Alkyne Cycloadditions: New Insights and Perspectives
Author(s) -
Lutz JeanFrançois
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705365
Subject(s) - cycloaddition , azide , alkyne , copper , click chemistry , chemistry , combinatorial chemistry , transition metal , catalysis , organic chemistry
Clicking without copper : Copper‐mediated azide–alkyne “click” cycloadditions (CuAAC) play a central role in contemporary synthetic chemistry but rely on transition‐metal catalysts, which hamper their adoption in some biological applications. Recently, the strain‐promoted and fluorine‐activated cycloaddition of cyclooctynes and organic azides (see picture) was proposed as an interesting metal‐free alternative to CuAAC.