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Catalytic Enantioselective Aldol‐type Reaction of β‐Ketosters with Acetals
Author(s) -
Umebayashi Natsuko,
Hamashima Yoshitaka,
Hashizume Daisuke,
Sodeoka Mikiko
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705344
Subject(s) - aldol reaction , enantioselective synthesis , cationic polymerization , electrophile , catalysis , chemistry , organic chemistry , combinatorial chemistry
Two activations, one catalyst : By using cationic Pd and Pt complexes, a catalytic enantioselective aldol‐type reaction of β‐ketoesters with acetals has been developed (see scheme). The formation of metal enolates occurs under acidic conditions to allow the use of acetals as electrophiles to give the desired aldol products in high diastereoseletivity and enantioselectivity.