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Spectroscopically Enhancing Electrical Nanotraps
Author(s) -
Zheng Gengfeng,
Qin Lidong,
Mirkin Chad A.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705312
Subject(s) - raman spectroscopy , microfluidics , nanotechnology , lithography , oligonucleotide , sample (material) , nanometre , materials science , analytical chemistry (journal) , chemistry , optoelectronics , physics , dna , optics , environmental chemistry , chromatography , biochemistry , composite material
Electrical traps with Raman hot spots : On‐wire‐lithography (OWL) nanotraps electrically localize DNA in a nanometer‐scale gap (see picture, red oligonucleotides with Raman dyes), which allows for the identification of the localized material by surface‐enhanced Raman spectroscopy. With microfluidic delivery, sample volumes as small as 1 μL with target concentrations as low as 230 f M can be studied without secondary amplification.