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Synthesis of Platensimycin
Author(s) -
Tiefenbacher Konrad,
Mulzer Johann
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705303
Subject(s) - chemistry , streptomyces , combinatorial chemistry , drug discovery , antibiotics , organic chemistry , stereochemistry , biochemistry , biology , bacteria , genetics
In modern drug discovery, antibodies or libraries of simple synthetic organic compounds, mostly of heterocyclic origin, are favored. Natural products play an increasingly inferior role as they are considered structurally too complex, limited in quantity, and difficult to synthesize, manipulate, and derivatize. Thus it was a sensation when a Merck research group reported that classical screening of metabolites from Streptomyces platensis has unearthed a low‐molecular‐weight organic compound with remarkable antibiotic properties.