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Proximicins A, B, and C—Antitumor Furan Analogues of Netropsin from the Marine Actinomycete Verrucosispora Induce Upregulation of p53 and the Cyclin Kinase Inhibitor p21
Author(s) -
Schneider Kathrin,
Keller Simone,
Wolter Falko E.,
Röglin Lars,
Beil Winfried,
Seitz Oliver,
Nicholson Graeme,
Bruntner Christina,
Riedlinger Julia,
Fiedler HansPeter,
Süssmuth Roderich D.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705295
Subject(s) - netropsin , downregulation and upregulation , kinase , cyclin , stereochemistry , chemistry , furan , biochemistry , biology , cell cycle , cell , dna , organic chemistry , gene , minor groove
Drugs from the sea : Three new netropsin‐type antibiotics ( 1 – 3 ) with a hitherto unknown furan core structure have been isolated from marine actinomycete strains and their structures elucidated by means of mass spectrometry and 2D NMR spectroscopy. The compounds show antitumor activity and, in contrast to netropsin, they induce upregulation of p53 and the cyclin kinase inhibitor p21.