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Direct, Iridium‐Catalyzed Enantioselective and Regioselective Allylic Etherification with Aliphatic Alcohols
Author(s) -
Ueno Satoshi,
Hartwig John F.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705267
Subject(s) - regioselectivity , allylic rearrangement , library science , iridium , chemistry , enantioselective synthesis , computer science , organic chemistry , catalysis
From alcohol to ether : Iridium‐catalyzed allylations yield α chiral ether derivatives directly from aliphatic alcohols with a simple alkali metal base (see equation). These reactions form ethers from primary, secondary, and tertiary alkoxides with high enantioselectivity. By‐products from isomerization were suppressed by the use of an alkyne additive.