Premium
Proteins in Mesoporous Silicates
Author(s) -
Hudson Sarah,
Cooney Jakki,
Magner Edmond
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705238
Subject(s) - mesoporous material , macromolecule , biocatalysis , chemistry , proteases , nanotechnology , molecule , materials science , biomolecule , enzyme , organic chemistry , biochemistry , catalysis , ionic liquid
Mesoporous silicates (MPS) have an ordered pore structure with dimensions comparable to many biological molecules. They have been extensively explored as supports for proteins and enzymes in biocatalytic applications. Since their initial discovery, novel syntheses methods have led to precise control over pore size and structure, particle size, chemical composition, and stability, thus allowing the adsorption of a wide variety of biological macromolecules, such as heme proteins, lipases, antibody fragments, and proteases, into their structures. This Review discusses the application of ordered, large‐pore, functionalized mesoporous silicates to immobilize proteins for biocatalysis.