Premium
METAMORPhos: Adaptive Supramolecular Ligands and Their Mechanistic Consequences for Asymmetric Hydrogenation
Author(s) -
Patureau Frederic W.,
Kuil Mark,
Sandee Albertus J.,
Reek Joost N. H.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705212
Subject(s) - denticity , enantioselective synthesis , supramolecular chemistry , asymmetric hydrogenation , chemistry , combinatorial chemistry , sulfonamide , rhodium , catalysis , mechanism (biology) , stereochemistry , organic chemistry , molecule , crystal structure , philosophy , epistemology
Adapt to react : METAMORPhos ligands are a class of flexible and adaptive hydrogen‐bonded multidentate sulfonamide‐based phosphorus ligands. Selective formation of complexes with two different METAMORPhos ligands (see scheme) that display unusual kinetic behavior leads to the proposal of a new mechanism. These complexes are highly reactive and enantioselective in the rhodium‐catalyzed asymmetric hydrogenation of alkenes.