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Ru‐Catalyzed Tandem Cross‐Metathesis/Intramolecular‐Hydroarylation Sequence
Author(s) -
Chen JiaRong,
Li ChangFeng,
An XiaoLei,
Zhang JiJi,
Zhu XiaoYu,
Xiao WenJing
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705194
Subject(s) - tandem , intramolecular force , metathesis , ruthenium , catalysis , sequence (biology) , chemistry , combinatorial chemistry , indole test , salt metathesis reaction , stereochemistry , organic chemistry , materials science , polymerization , biochemistry , composite material , polymer
Sometimes it only takes one to tango : A novel ruthenium‐catalyzed tandem cross‐metathesis/intramolecular‐hydroarylation reaction of alkenyl indoles has been developed which relies on a single catalyst for the tandem sequence and provides an efficient synthesis of fused polycyclic indole compounds with good to excellent overall yields (see scheme; Ts=4‐toluenesulfonyl, DCE=1,2‐dichloroethane, Mes=2,4,6‐Me 3 C 6 H 2 ).