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Mass Spectrometric Screening of Chiral Catalysts by Monitoring the Back Reaction of Quasienantiomeric Products: Palladium‐Catalyzed Allylic Substitution
Author(s) -
Müller Constanze A.,
Pfaltz Andreas
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705081
Subject(s) - allylic rearrangement , palladium , catalysis , substitution (logic) , chemistry , substitution reaction , combinatorial chemistry , organic chemistry , computer science , programming language
Back to basics : The principle of microscopic reversibility is the basis of a new screening method for chiral catalysts. Monitoring the back reaction of quasienantiomeric allylation products by ESI‐MS reveals the intrinsic enantioselectivity of palladium catalysts in allylic substitution reactions (see scheme).