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A Chiral Pool Based Synthesis of Platensimycin
Author(s) -
Nicolaou K. C.,
Pappo Doron,
Tsang Kit Y.,
Gibe Romelo,
Chen David Y.K.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705080
Subject(s) - broad spectrum , carvone , computer science , combinatorial chemistry , chemistry , stereochemistry , information retrieval , world wide web , food science , essential oil , limonene
Extensive pharming : An expedient entry into the tetracycle 2 , a late‐stage synthetic intermediate en route to the broad‐spectrum antibiotic (−)‐platensimycin ( 1 ) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material ( R )‐(−)‐carvone.