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Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2 R ,3 S )‐Isocitric Acid by Fermentation of Sunflower Oil
Author(s) -
Heretsch Philipp,
Thomas Franziska,
Aurich Andreas,
Krautscheid Harald,
Sicker Dieter,
Giannis Athanassios
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705000
Subject(s) - citric acid , sunflower oil , chemistry , fermentation , sunflower , scale (ratio) , organic chemistry , food science , biology , physics , horticulture , quantum mechanics
No longer just analytical : Previously, (2 R ,3 S )‐isocitric acid ( 1 ), a component of the citric acid cycle, had not been available on a preparative scale. A new route to this acid on a kilogram scale combines a biotechnological formation through fermentation from sunflower oil with a chemical separation process. In a variety of transformations into further chiral derivatives, 1 is established as a valuable new member of the chiral pool (see scheme).