Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2 R ,3 S )‐Isocitric Acid by Fermentation of Sunflower Oil | Zendy

Heretsch Philipp | Zendy; Thomas Franziska | Zendy; Aurich Andreas | Zendy; Krautscheid Harald | Zendy; Sicker Dieter | Zendy; Giannis Athanassios | Zendy

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Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2 R ,3 S )‐Isocitric Acid by Fermentation of Sunflower Oil

Author(s) -

Heretsch Philipp,

Thomas Franziska,

Aurich Andreas,

Krautscheid Harald,

Sicker Dieter,

Giannis Athanassios

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200705000

Subject(s) - citric acid , sunflower oil , chemistry , fermentation , sunflower , scale (ratio) , organic chemistry , food science , biology , physics , horticulture , quantum mechanics

No longer just analytical : Previously, (2 R ,3 S )‐isocitric acid ( 1 ), a component of the citric acid cycle, had not been available on a preparative scale. A new route to this acid on a kilogram scale combines a biotechnological formation through fermentation from sunflower oil with a chemical separation process. In a variety of transformations into further chiral derivatives, 1 is established as a valuable new member of the chiral pool (see scheme).

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