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A Portable Albumin Binder from a DNA‐Encoded Chemical Library
Author(s) -
Dumelin Christoph E.,
Trüssel Sabrina,
Buller Fabian,
Trachsel Eveline,
Bootz Frank,
Zhang Yixin,
Mannocci Luca,
Beck Susanne C.,
DrumeaMirancea Mihaela,
Seeliger Mathias W.,
Baltes Christof,
Müggler Thomas,
Kranz Felicitas,
Rudin Markus,
Melkko Samu,
Scheuermann Jörg,
Neri Dario
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704936
Subject(s) - albumin , in vivo , contrast (vision) , fluorescein , computer science , class (philosophy) , pharmacokinetics , chemistry , computational biology , artificial intelligence , biochemistry , optics , medicine , pharmacology , biology , physics , fluorescence , genetics
Seeing eye to eye : Plasma‐protein binding is effective in improving the pharmacokinetic properties of otherwise short‐lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half‐life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture).