Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the Myxobacterium  Sorangium cellulosum | Zendy

Bock Martin | Zendy; Buntin Kathrin | Zendy; Müller Rolf | Zendy; Kirschning Andreas | Zendy

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Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the Myxobacterium Sorangium cellulosum

Author(s) -

Bock Martin,

Buntin Kathrin,

Müller Rolf,

Kirschning Andreas

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200704897

Subject(s) - stereocenter , derivatization , absolute configuration , chemistry , stereochemistry , computational biology , antibiotics , biochemistry , biology , mass spectrometry , enantioselective synthesis , chromatography , catalysis

Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A–C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes.

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