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Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the Myxobacterium Sorangium cellulosum
Author(s) -
Bock Martin,
Buntin Kathrin,
Müller Rolf,
Kirschning Andreas
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704897
Subject(s) - stereocenter , derivatization , absolute configuration , chemistry , stereochemistry , computational biology , antibiotics , biochemistry , biology , mass spectrometry , enantioselective synthesis , chromatography , catalysis
Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A–C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes.