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Extending the Scope of Native Chemical Peptide Coupling
Author(s) -
Haase Christian,
Seitz Oliver
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704886
Subject(s) - scope (computer science) , native chemical ligation , peptide , thioester , coupling (piping) , chemistry , combinatorial chemistry , computer science , nanotechnology , chemical synthesis , engineering , biochemistry , materials science , programming language , mechanical engineering , enzyme , in vitro
The two bottlenecks for native chemical ligation are the limitations of thioester syntheses and a lack of suitable coupling sites in peptide sequences. This Highlight describes current advances that are capable of extending the scope of these methods, such as radical desulfurization (see scheme).