Premium
Avian Influenza H5‐Containing Virus‐Like Particles (VLPs): Host‐Cell Receptor Specificity by STD NMR Spectroscopy
Author(s) -
Haselhorst Thomas,
Garcia JeanMichel,
Islam Tasneem,
Lai Jimmy C. C.,
Rose Faith J.,
Nicholls John M.,
Peiris J. S. Malik,
von Itzstein Mark
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704872
Subject(s) - hemagglutinin (influenza) , virology , virus , avian influenza virus , influenza a virus subtype h5n1 , influenza a virus , host (biology) , biology , pandemic , nuclear magnetic resonance spectroscopy , chemistry , covid-19 , medicine , genetics , stereochemistry , infectious disease (medical specialty) , disease , pathology
Gripped by the flu : The emergence of a human pandemic influenza virus from an avian progenitor involves a switch in preferential binding of the influenza virus hemagglutinin (HA). Saturation transfer difference NMR spectroscopy of avian H5 chimeric virus‐like particles (VLPs) encoding viral HA in a complex with α(2,3)‐and α(2,6)‐linked N ‐acetylneuraminides (3′SL and 6′SL, respectively) has shown that avian influenza H5‐containing VLPs clearly discriminate between α(2,3)‐ and α(2,6)‐linkages.