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Fluorous Tags Catching on Microarrays
Author(s) -
Pohl Nicola L.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704801
Subject(s) - surface plasmon resonance , histone deacetylase , dna microarray , chemistry , combinatorial chemistry , protein array analysis , bioassay , nanotechnology , small molecule , molecule , protein microarray , chromatography , histone , biochemistry , materials science , organic chemistry , biology , gene expression , genetics , dna , gene , nanoparticle
Tag team : Not only hydrophilic carbohydrates but also hydrophobic compounds such as histone deacetylase inhibitors and biotin can be incorporated into fluorous‐based small‐molecule microarrays. A range of fluorous‐tagged molecules can be patterned and screened for bioactivity on a fluorous surface with hit rates comparable to those seen by solution‐based and surface plasmon resonance‐based bioassays.