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Optical Detection of Glucose and Acetylcholine Esterase Inhibitors by H 2 O 2 ‐Sensitive CdSe/ZnS Quantum Dots
Author(s) -
Gill Ron,
Bahshi Lily,
Freeman Ronit,
Willner Itamar
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704794
Subject(s) - quantum dot , fluorescence , fluorophore , acetylcholine , chemistry , esterase , enzyme , coupling (piping) , optoelectronics , materials science , biochemistry , biology , physics , optics , endocrinology , metallurgy
The coupling of oxidases with fluorophore‐labeled CdSe/ZnS quantum dots enables the ratiometric fluorescence analysis of enzyme activities and their substrates by the interaction between the biocatalytically generated H 2 O 2 and the quantum dots. The method has been applied to the analyis of glucose and the inhibition of acetylcholine esterase.