Premium
dsRNA‐Functionalized Multifunctional γ‐Fe 2 O 3 Nanocrystals: A Tool for Targeting Cell Surface Receptors
Author(s) -
Shukoor Mohammed Ibrahim,
Natalio Filipe,
Metz Nadine,
Glube Natalie,
Tahir Muhammad Nawaz,
Therese Helen Annal,
Ksenofontov Vadim,
Theato Patrick,
Langguth Peter,
Boissel JeanPaul,
Schröder Heinz C.,
Müller Werner E. G.,
Tremel Wolfgang
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704735
Subject(s) - tlr3 , receptor , cell , immunostaining , chemistry , surface modification , nanoparticle , materials science , biophysics , nanotechnology , microbiology and biotechnology , biochemistry , biology , toll like receptor , innate immune system , immunohistochemistry , immunology
Specific cell recognition : Magnetic γ‐Fe 2 O 3 nanoparticles (MNPs) functionalized with a fluorescently labeled polymer and polyinosinic‐polycytidylic acid [poly(I:C)] allow the specific visualizion of the TLR3 receptors on the the surface of Caki‐1 cells. The expression of TLR3 on the Caki‐1 cells was demonstrated independently by RT‐PCR and immunostaining techniques.