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Pure CH Hydrogen Bonding to Chloride Ions: A Preorganized and Rigid Macrocyclic Receptor
Author(s) -
Li Yongjun,
Flood Amar H.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704717
Subject(s) - steric effects , hydrogen bond , chloride , ion , chemistry , dual (grammatical number) , hydrogen , combinatorial chemistry , crystallography , molecule , stereochemistry , organic chemistry , philosophy , linguistics
Strength in numbers : When traditionally weak CH hydrogen bonds are preorganized in a shape‐persistent macrocycle, a strong affinity for chloride ions emerges. This discovery arises from the dual use of click chemistry for efficient macrocyclization and the favorable steric properties of the resulting 1,2,3‐triazoles.
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