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Construction of DNA Architectures with RNA Hairpins
Author(s) -
Mayer Günter,
Ackermann Damian,
Kuhn Nicole,
Famulok Michael
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704709
Subject(s) - dna , rna , computational biology , computer science , biology , chemistry , genetics , gene
Kissing complexes formed on the basis of highly specific noncanonical interactions of RNA hairpins can be harnessed for the controlled assembly of DNA nanoobjects. Two DNA minicircles, each equipped with a different RNA hairpin motif (see picture), mediate a tight and specific binding of the two circular DNA nanoobjects. These interactions may offer the possibility to construct DNA nanoobjects with increased complexity.