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Catalytic Asymmetric Fluorination Comes of Age
Author(s) -
Brunet Vincent A.,
O'Hagan David
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704700
Subject(s) - enantioselective synthesis , stereocenter , context (archaeology) , catalysis , reagent , chemistry , organic chemistry , stereochemistry , combinatorial chemistry , geography , archaeology
Gimme an F : Ever since the first asymmetric fluorination reagents were reported in 1988, the enantioselective introduction of a CF bond at a stereogenic center has emerged as a major objective in organic chemistry. Newly published results on the enantioselective fluorination of malonates (see scheme) are put into context in this Highlight. NFSI= N ‐fluorodibenzenesulfonimide.