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Highly Efficient Ruthenium(II) Porphyrin Catalyzed Amidation of Aldehydes
Author(s) -
Chang Joyce Wei Wei,
Chan Philip Wai Hong
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704695
Subject(s) - ruthenium , porphyrin , catalysis , chemistry , combinatorial chemistry , organic chemistry
H to N : The first example of a mild, highly efficient CH bond amidation catalyzed by ruthenium(II) porphyrin complexes uses PhINTs as the nitrogen source for installing the amide bond functionality in a wide variety of aldehydes (see scheme). The protocol is chemoselective, with the new CN bond forming only at the acyl CH bond, even in aldehyde substrates containing other functional groups.