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Protein Crystallography through Supramolecular Interactions between a Lanthanide Complex and Arginine
Author(s) -
Pompidor Guillaume,
D'Aléo Anthony,
Vicat Jean,
Toupet Loïc,
Giraud Nicolas,
Kahn Richard,
Maury Olivier
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704683
Subject(s) - lanthanide , supramolecular chemistry , crystallography , titration , chemistry , diffraction , luminescence , crystal structure , materials science , physics , organic chemistry , ion , optoelectronics , optics
Crystal clear : Strong supramolecular interactions between tris(dipicolinate)lanthanide complexes and arginine‐like moieties have been evidenced by NMR chemical shift titration and X‐ray diffraction analyses. Since the lanthanide atom is a strong anomalous scatterer, and the complex itself is luminescent, this interaction could be used as a powerful tool in the preparation of crystals of protein derivatives with high phasing power.