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Catalytic Asymmetric Reaction with Water: Enantioselective Synthesis of α‐Hydroxyesters by a Copper–Carbenoid OH Insertion Reaction
Author(s) -
Zhu ShouFei,
Chen Chao,
Cai Yan,
Zhou QiLin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704651
Subject(s) - carbenoid , enantioselective synthesis , catalysis , chemistry , copper , metal , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , rhodium
Taking on water : A novel catalytic asymmetric metal–carbenoid insertion reaction with water has been developed with copper complexes of chiral spiro bisoxazoline ligands as catalysts. This reaction provides an efficient and practical procedure for preparing chiral α‐hydroxyesters and acids starting from readily available materials in high yields and enantioselectivities. BAr F − =[B{3,5‐(CF 3 ) 2 C 6 H 3 )} 4 ] − .