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Palladium‐Catalyzed Direct Arylation of (Hetero)Arenes with Aryl Boronic Acids
Author(s) -
Yang ShangDong,
Sun ChangLiang,
Fang Zhao,
Li BiJie,
Li YiZhou,
Shi ZhangJie
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704619
Subject(s) - aryl , chemistry , palladium , catalysis , combinatorial chemistry , boronic acid , suzuki reaction , organic chemistry , alkyl
No compass required: A method is described for forming biaryl CC bonds by a Pd II ‐catalyzed cross‐coupling of aryl CH bonds with aryl boronic acids under mild conditions without the presence of directing groups. Different substituents on both (hetero)arenes and aryl boronic acids are compatible with the reaction conditions, and the homocoupling of boronic acids is highly inhibited. Dioxygen was applied as the final oxidant.