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Asymmetric Synthesis and Biological Properties of Uncialamycin and 26‐ epi ‐Uncialamycin
Author(s) -
Nicolaou K. C.,
Chen Jason S.,
Zhang Hongjun,
Montero Ana
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704577
Subject(s) - enantioselective synthesis , epimer , stereochemistry , broad spectrum , combinatorial chemistry , chemistry , biochemistry , catalysis
The highly potent DNA‐cleaving molecule uncialamycin ( 1 ) was prepared in an asymmetric total synthesis featuring an enantioselective Noyori reduction. Compound 1 and its C26 epimer exhibit impressive broad‐spectrum antibacterial properties and highly potent antitumor activities against a variety of cell lines.