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HIV TAT Forms Pores in Membranes by Inducing Saddle‐Splay Curvature: Potential Role of Bidentate Hydrogen Bonding
Author(s) -
Mishra Abhijit,
Gordon Vernita D.,
Yang Lihua,
Coridan Robert,
Wong Gerard C. L.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704444
Subject(s) - membrane , saddle , curvature , hydrogen bond , chemistry , saddle point , human immunodeficiency virus (hiv) , physics , nanotechnology , crystallography , chemical physics , materials science , engineering , geometry , molecule , mechanical engineering , mathematics , quantum mechanics , virology , biochemistry , biology
Pore performance : The TAT protein of HIV can cross cell membranes with remarkable efficiency. By applying ideas from coordination chemistry, soft‐condensed‐matter physics, and differential geometry, it has been shown that TAT induces saddle‐splay curvature in cell membranes, a process that is required for pore formation (see picture of two nonintersecting networks of pores). The results have potential implications for the design of cell‐penetrating peptides.