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A Bioluminescent Molecular Switch For Glucose
Author(s) -
Teasley Hamorsky Krystal,
Ensor C. Mark,
Wei Yinan,
Daunert Sylvia
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704440
Subject(s) - bioluminescence , aequorin , molecular switch , sugar , molecular recognition , chemistry , biophysics , biochemistry , biology , molecule , organic chemistry , intracellular
Glowing after a sugar rush : A molecular switch is formed by inserting glucose‐binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.