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Reactions of a Copper(II) Superoxo Complex Lead to CH and OH Substrate Oxygenation: Modeling Copper‐Monooxygenase CH Hydroxylation
Author(s) -
Maiti Debabrata,
Lee DongHeon,
Gaoutchenova Katya,
Würtele Christian,
Holthausen Max C.,
Narducci Sarjeant Amy A.,
Sundermeyer Jörg,
Schindler Siegfried,
Karlin Kenneth D.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704389
Subject(s) - hydroxylation , copper , monooxygenase , chemistry , substrate (aquarium) , oxygenation , stereochemistry , photochemistry , organic chemistry , enzyme , biology , ecology , cytochrome p450
Donor makes the difference : The mononuclear η 1 ‐superoxo copper(II) complex 1 undergoes dioxygen activation with the addition of hydrogen‐atom donors. Net O 2 ‐derived O‐atom insertion into the N ‐methyl group of the ligand leads to formation of a copper(II)‐alkoxide product 2 . The cupric superoxo species 1 itself is not capable of the observed hydroxylation reaction.