Reactions of a Copper(II) Superoxo Complex Lead to CH and OH Substrate Oxygenation: Modeling Copper‐Monooxygenase CH Hydroxylation | Zendy

Maiti Debabrata | Zendy; Lee DongHeon | Zendy; Gaoutchenova Katya | Zendy; Würtele Christian | Zendy; Holthausen Max C. | Zendy; Narducci Sarjeant Amy A. | Zendy; Sundermeyer Jörg | Zendy; Schindler Siegfried | Zendy; Karlin Kenneth D. | Zendy

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Reactions of a Copper(II) Superoxo Complex Lead to CH and OH Substrate Oxygenation: Modeling Copper‐Monooxygenase CH Hydroxylation

Author(s) -

Maiti Debabrata,

Lee DongHeon,

Gaoutchenova Katya,

Würtele Christian,

Holthausen Max C.,

Narducci Sarjeant Amy A.,

Sundermeyer Jörg,

Schindler Siegfried,

Karlin Kenneth D.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200704389

Subject(s) - hydroxylation , copper , monooxygenase , chemistry , substrate (aquarium) , oxygenation , stereochemistry , photochemistry , organic chemistry , enzyme , biology , ecology , cytochrome p450

Donor makes the difference : The mononuclear η 1 ‐superoxo copper(II) complex 1 undergoes dioxygen activation with the addition of hydrogen‐atom donors. Net O 2 ‐derived O‐atom insertion into the N ‐methyl group of the ligand leads to formation of a copper(II)‐alkoxide product 2 . The cupric superoxo species 1 itself is not capable of the observed hydroxylation reaction.

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