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Combinatorial Transition‐Metal Catalysis: Mixing Monodentate Ligands to Control Enantio‐, Diastereo‐, and Regioselectivity
Author(s) -
Reetz Manfred T.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704327
Subject(s) - regioselectivity , denticity , catalysis , transition metal , chemistry , combinatorial chemistry , homogeneous , homogeneous catalysis , modular design , mixing (physics) , metal , stereochemistry , organic chemistry , computer science , mathematics , physics , combinatorics , quantum mechanics , operating system
This review focuses on a new approach to combinatorial homogeneous transition‐metal catalysis which goes beyond the traditional parallel preparation of modular ligands. It is based on the use of mixtures of monodentate ligands L a and L b , which upon exposure to a transition metal (M) form not only the two homocombinations [ML a L a ] and [ML b L b ], but also the heterocombination [ML a L b ]. If the latter is more reactive and selective than the homocombinations, an improved catalyst system is formed without the need to synthesize new ligands. Thus, the control of enantio,‐ diastereo‐, and regioselectivity is possible.