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Catalytic Enantioselective Passerini Three‐Component Reaction
Author(s) -
Wang ShiXin,
Wang MeiXiang,
Wang DeXian,
Zhu Jieping
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704315
Subject(s) - enantioselective synthesis , catalysis , component (thermodynamics) , chemistry , combinatorial chemistry , organic chemistry , stereochemistry , physics , thermodynamics
Make it enantioselective : The [(salen)Al III Cl] complex 1 catalyzes the title reaction of an aldehyde, a carboxylic acid, and an isocyanide to afford α‐acyloxyamides 2 with good to excellent enantioselectivity. A variety of nonchelating substrates can be used to generate the versatile chiral products. R 1 =alkyl; R 2 =alkyl, alkenyl, aryl; R 3 =alkyl, aryl.
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