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Mercury–Alkyl Bond Cleavage Based on Organomercury Lyase
Author(s) -
Strasdeit Henry
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704275
Subject(s) - chemistry , lyase , organomercury compounds , stereochemistry , alkyl , bond cleavage , moiety , protonolysis , enzyme , mercury (programming language) , protonation , alkene , substituent , active site , metal , organic chemistry , catalysis , programming language , computer science , ion
Cleaning up without enzymes : Alkyl mercury cations are poorly degradable. Protonolysis of HgC bonds by bacteria takes place with the aid of organomercury lyase, and functional models based on dihydroimidazolethione ligands have been recently reported. Relatively high metal coordination numbers (e.g. 4, see figure) are the key to bond activation and thus to non‐enzymatic detoxification of the neurotoxic methylmercury cation.