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Synthesis and Quantitative Evaluation of Glycero ‐ D ‐ manno ‐heptose Binding to Concanavalin A by Fluorous‐Tag Assistance
Author(s) -
Jaipuri Firoz A.,
Collet Beatrice Y. M.,
Pohl Nicola L.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704262
Subject(s) - concanavalin a , mannose , chemistry , ligand (biochemistry) , biochemistry , receptor , in vitro
Fooling conA? Fluorous microarrays allow not only qualitative, but also quantitative assessment of binding to show that conA can accept modifications to its usual mannose ligand at the C‐6 position and bind to bacterial seven‐carbon mannose analogues.