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Kinetic Resolution and Desymmetrization by Stereoselective Silylation of Alcohols
Author(s) -
Rendler Sebastian,
Oestreich Martin
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704210
Subject(s) - desymmetrization , kinetic resolution , silylation , acylation , stereoselectivity , chemistry , reagent , catalysis , substrate (aquarium) , organic chemistry , enantioselective synthesis , stereochemistry , oceanography , geology
Watch out asymmetric acylation! Non‐enzymatic kinetic resolution and desymmetrization by the asymmetric acylation of alcohols has found its rival in the related silylation of alcohols. The scheme shows the two‐point binding of the substrate in catalyst‐ (left) and reagent‐controlled stereoselective silylation (right).