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Asymmetric Counteranion‐Directed Catalysis for the Epoxidation of Enals
Author(s) -
Wang Xingwang,
List Benjamin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704185
Subject(s) - catalysis , chemistry , combinatorial chemistry , organic chemistry
A new mode of chiral anion catalysis : A powerful chiral‐counteranion strategy for catalytic asymmetric epoxidations using the newly discovered catalyst 1 has been applied to the epoxidation of α,β‐unsaturated aldehydes together with tert ‐butyl hydroperoxide as the oxidant (see scheme). Remarkably, this system provides the corresponding epoxides in high diastereo‐ and enantioselectivity for both di‐ and trisubstituted enals.