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Highly Efficient Catalytic System for Enantioselective Michael Addition of Aldehydes to Nitroalkenes in Water
Author(s) -
Zhu Shaolin,
Yu Shouyun,
Ma Dawei
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704161
Subject(s) - michael reaction , enantioselective synthesis , organocatalysis , benzoic acid , catalysis , chemistry , trimethylsilyl , organic chemistry , computer science , combinatorial chemistry
Organocatalysis : A highly effective catalytic procedure for the Michael addition of aldehydes to nitroalkenes is achieved by combining the excellent asymmetric induction ability of o ‐TMS‐protected diphenylprolinol compounds, the quick formation of enamines in the presence of benzoic acid, and the highly concentrated organic phase in water (see scheme; TMS=trimethylsilyl).