Highly Efficient Catalytic System for Enantioselective Michael Addition of Aldehydes to Nitroalkenes in Water | Zendy

Zhu Shaolin | Zendy; Yu Shouyun | Zendy; Ma Dawei | Zendy

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Highly Efficient Catalytic System for Enantioselective Michael Addition of Aldehydes to Nitroalkenes in Water

Author(s) -

Zhu Shaolin,

Yu Shouyun,

Ma Dawei

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200704161

Subject(s) - michael reaction , enantioselective synthesis , organocatalysis , benzoic acid , catalysis , chemistry , trimethylsilyl , organic chemistry , computer science , combinatorial chemistry

Organocatalysis : A highly effective catalytic procedure for the Michael addition of aldehydes to nitroalkenes is achieved by combining the excellent asymmetric induction ability of o ‐TMS‐protected diphenylprolinol compounds, the quick formation of enamines in the presence of benzoic acid, and the highly concentrated organic phase in water (see scheme; TMS=trimethylsilyl).

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