Premium
Capture and Release of Protein by a Reversible DNA‐Induced Sol–Gel Transition System
Author(s) -
Wei Bryan,
Cheng Immensee,
Luo Kathy Q.,
Mi Yongli
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704143
Subject(s) - dna , duplex (building) , base pair , biophysics , chemistry , transition (genetics) , pairing , thrombin , biochemistry , biology , physics , gene , superconductivity , platelet , quantum mechanics , immunology
Cross‐links holding on, then letting go : Polyacrylamide main chains were branched with DNA strands, which could be gelatinized by DNA base pairing with a thrombin‐bound cross‐linking strand (see scheme). A complementary DNA strand can form a duplex with the cross‐linking strand to dissolve the hydrogel and release the thrombin.