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Immortalizing a Transient Electrophile for DNA Cross‐Linking
Author(s) -
Wang Huan,
Wahi Manvinder S.,
Rokita Steven E.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704137
Subject(s) - electrophile , nucleophile , transient (computer programming) , dna , computer science , quinone methide , chemistry , quinone , aqueous solution , scheme (mathematics) , combinatorial chemistry , biochemistry , organic chemistry , programming language , mathematics , mathematical analysis , catalysis
Who wants to live forever? Compounds that act as strong nucleophiles and good leaving groups repeatedly capture and release a transient quinone methide to extend its effective lifetime under aqueous conditions and promote DNA cross‐linking (see scheme). This finding may expand the biological and therapeutic activity of quinone methides.