Total Synthesis and Stereochemical Reassignment of (+)‐Neopeltolide | Zendy

Youngsaye Willmen | Zendy; Lowe Jason T. | Zendy; Pohlki Frauke | Zendy; Ralifo Paul | Zendy; Panek James S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis and Stereochemical Reassignment of (+)‐Neopeltolide

Author(s) -

Youngsaye Willmen,

Lowe Jason T.,

Pohlki Frauke,

Ralifo Paul,

Panek James S.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200704122

Subject(s) - stereocenter , enantioselective synthesis , total synthesis , computer science , annulation , oxazole , construct (python library) , stereochemistry , chemistry , programming language , organic chemistry , catalysis

Take a closer look! The first enantioselective total synthesis, stereochemical reassignment, and absolute configuration of the metabolite neopeltolide is described (see picture). Synthetic highlights of this route include a modified Evans–Tishchenko reduction to introduce the C11 stereocenter, [4+2] annulation to construct the pyran system, and a Still–Gennari olefination to install the oxazole side chain.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research