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Highly Enantioselective Hydrophosphonylation of Aldehydes Catalyzed by Tridentate Schiff Base Aluminum(III) Complexes
Author(s) -
Zhou Xin,
Liu Xiaohua,
Yang Xu,
Shang Deju,
Xin Junguo,
Feng Xiaoming
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704116
Subject(s) - schiff base , enantioselective synthesis , aluminium , base (topology) , catalysis , chemistry , combinatorial chemistry , organic chemistry , medicinal chemistry , database , computer science , stereochemistry , mathematics , mathematical analysis
Active in dimeric form : A tridentate Schiff base aluminum(III) complex has been applied in the asymmetric hydrophosphonylation of various aldehydes, giving the corresponding products in good yields with good to excellent ee values (up to 97 %). The strong positive nonlinear effect, along with high‐resolution MS analyses, indicates that the reaction is performed in the presence of a dimeric aluminum species. Ad=adamantyl.