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Nickel/BPh 3 ‐Catalyzed Alkynylcyanation of Alkynes and 1,2‐Dienes: An Efficient Route to Highly Functionalized Conjugated Enynes
Author(s) -
Nakao Yoshiaki,
Hirata Yasuhiro,
Tanaka Masaaki,
Hiyama Tamejiro
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704095
Subject(s) - catalysis , conjugated system , nickel , chemistry , enyne , combinatorial chemistry , lewis acids and bases , molecule , polymer chemistry , medicinal chemistry , organic chemistry , polymer
Adding across : A C(sp)C(sp) bond of alkynyl cyanides is activated by nickel/Lewis acid catalysis derived from [Ni(cod) 2 ] and BPh 3 , and the alkynylcyanation reaction of alkynes and 1,2‐dienes is achieved by the binary catalysis for the first time to give a range of functionalized conjugated enyne molecules with defined stereo‐ and regioselectivities.