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Tip‐Enhanced Raman Spectroscopy of Single RNA Strands: Towards a Novel Direct‐Sequencing Method
Author(s) -
Bailo Elena,
Deckert Volker
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704054
Subject(s) - raman spectroscopy , biomolecule , rna , raman scattering , nucleobase , microscope , microscopy , materials science , chemistry , dna , nanotechnology , optics , physics , gene , biochemistry
Walking the strand : Tip‐enhanced Raman scattering (TERS) with precision probe positioning has been used to obtain high‐quality Raman spectra of the nucleobases in a single RNA strand (see picture: foreground Raman spectrum, background atomic‐force microscope tip positioned over the RNA strand). This procedure represents the first step towards direct and label‐free single‐biomolecule sequencing.