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Structural Aspects of Nucleation Inhibitors for Diastereomeric Resolutions and the Relationship to Dutch Resolution
Author(s) -
Leeman Michel,
Brasile Giuseppina,
Gelens Edith,
Vries Ton,
Kaptein Bernard,
Kellogg Richard
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200704021
Subject(s) - diastereomer , resolution (logic) , mandelic acid , nucleation , crystallization , scheme (mathematics) , computer science , chemistry , content (measure theory) , combinatorial chemistry , stereochemistry , mathematics , organic chemistry , artificial intelligence , mathematical analysis
You say you want a resolution : Nucleation inhibitors for the resolution of diastereomers by selective crystallization have been designed and tested. The resolution of racemic 3‐methoxyphenylethylamine was optimized with ( S )‐mandelic acid as the resolving agent (see scheme). Multifunctional inhibitors are particularly effective.