DNA Minicircles with Gaps for Versatile Functionalization | Zendy

Rasched Goran | Zendy; Ackermann Damian | Zendy; Schmidt Thorsten L. | Zendy; Broekmann Peter | Zendy; Heckel Alexander | Zendy; Famulok Michael | Zendy

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DNA Minicircles with Gaps for Versatile Functionalization

Author(s) -

Rasched Goran,

Ackermann Damian,

Schmidt Thorsten L.,

Broekmann Peter,

Heckel Alexander,

Famulok Michael

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200704004

Subject(s) - minicircle , oligonucleotide , dna , sequence (biology) , computational biology , dna sequencing , biology , nanotechnology , materials science , genetics

Doing the rounds : A highly straightforward approach has been developed that provides access to DNA minicircles containing a 21‐mer single‐stranded gap region of defined sequence (see picture). The single‐stranded domain within a small circular DNA nanoobject provides the exciting opportunity to further functionalize a minicircle at defined positions in almost unlimited fashion, simply by hybridization with a synthetic 21‐mer oligonucleotide.

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