Palladium–( S , p  R )‐FerroNPS‐Catalyzed Asymmetric Allylic Etherification: Electronic Effect of Nonconjugated Substituents on Benzylic Alcohols on Enantioselectivity | Zendy

Lam Fuk Loi | Zendy; AuYeung Terry TinLok | Zendy; Kwong Fuk Yee | Zendy; Zhou Zhongyuan | Zendy; Wong Kwok Yin | Zendy; Chan Albert S. C. | Zendy

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Palladium–( S , p R )‐FerroNPS‐Catalyzed Asymmetric Allylic Etherification: Electronic Effect of Nonconjugated Substituents on Benzylic Alcohols on Enantioselectivity

Author(s) -

Lam Fuk Loi,

AuYeung Terry TinLok,

Kwong Fuk Yee,

Zhou Zhongyuan,

Wong Kwok Yin,

Chan Albert S. C.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703955

Subject(s) - allylic rearrangement , palladium , ferrocene , chemistry , enantioselective synthesis , catalysis , medicinal chemistry , stereochemistry , organic chemistry , combinatorial chemistry , electrochemistry , electrode

An enantioselective CO bond‐forming reaction proceeds well under palladium catalysis with newly developed N–P,S ligands with a ferrocene motif (see scheme). Nonconjugated substituents on the benzylic alcohol substrate lead to an increase in enantioselectivity with increasing electron‐donating ability in the title reaction with racemic 1,3‐diphenyl‐2‐propenyl acetate. Cy = cyclohexyl.

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