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MALDI In‐Source Photooxidation Reactions for Online Peptide Tagging
Author(s) -
Qiao Liang,
Roussel Christophe,
Wan Jingjing,
Kong Jilie,
Yang Pengyuan,
Girault Hubert H.,
Liu Baohong
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703876
Subject(s) - hydroquinone , redox , chemistry , cysteine , peptide , benzoquinone , desorption , photochemistry , ionization , combinatorial chemistry , matrix assisted laser desorption/ionization , inorganic chemistry , organic chemistry , biochemistry , ion , enzyme , adsorption
A TiO 2 photoelectrode array has been designed to achieve efficient photoelectrochemical redox reactions with electron donors or acceptors during the laser desorption ionization process. By adding hydroquinone to a peptide mixture, the photoelectrochemically generated benzoquinone reacts with the cysteine residues to selectively form tagged cysteine‐containing peptides, thus demonstrating that in‐source oxidation reactions can be efficiently performed.